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The USC Neurogenetics Multidisciplinary Program at Keck Medicine of USC in Los Angeles is designed to closely monitor the health of patients who have been diagnosed with certain diseases of the nervous system that occur due to family genetics or by spontaneous mutation of a gene. We offer advanced treatment to those patients if intervention becomes necessary. As an integral component in the continuum of care for patients who were diagnosed with neurogenetic conditions as children, our program extends care to patients as they move into adulthood. We also provide care to patients who have been diagnosed as adults.
Conditions treated in the program include neurofibromatosis 1, neurofibromatosis 2, Von Hippel-Lindau syndrome, Li–Fraumeni syndrome, tuberous sclerosis, Noonan syndrome and Costello syndrome. Patients who have these conditions can be symptom free, but can also be susceptible to a variety of malignant or benign tumors, including neurofibromas, astrocytomas, papillomas, acoustic neuromas, meningiomas, many of which can affect different parts of the body.
Surgery is the preferred method of treatment for tumors arising from these conditions. If a tumor does occur, it is important that diagnosis and treatment occur quickly. Therefore, our team follows each patient on an ongoing basis. We work in concert with members of the Adolescent and Young Adult Cancer Program at USC, which offers a unique breadth and scope of multidisciplinary treatment and care for adolescents and young adults.
In cases where a tumor is in a location in the body that makes surgery impossible or inadvisable, we are able to provide radiation therapy as alternate treatment. We offer the most advanced technologies in radiosurgery — such as TrueBeam™ Stx — in one location, providing our patients with the best possible course of treatment.
Additionally, researchers at USC are dedicated to finding innovative methods of care for each individual patient as we continue to deepen our understanding of the genetics responsible for these conditions. Patients can also be considered for inclusion in clinical trials, helping to accelerate the development of new and better diagnostic and treatment tools.
The USC Neurogenetics Multidisciplinary Program treats patients who have developed certain conditions due to family genetics or due to a spontaneous mutation of a gene.
These conditions include:
Our expert physicians and staff understand how these conditions affect our patients’ quality of lives, and we ensure that each patient is given the individualized treatment they need. Each patient’s health is continually monitored and followed, so that if they develop a tumor as a result of these conditions, our doctors can quickly react and develop an appropriate treatment plan.
The USC Neurogenetics Multidisciplinary Program works to identify patients who have certain conditions that arise as a result of family genetics, or a spontaneous mutation of a gene, and to closely monitor their health in case complications arise. In addition to identifying these conditions in adults, the program works closely with Children’s Hospital Los Angeles, so that as young patients with these conditions move into adulthood they can continue to be monitored and treated as necessary. Patients can go years with no problems or symptoms, but some will develop tumors in different areas of their body, including neurofibromas, astrocytomas, papillomas, acoustic neuromas and meningiomas. Therefore, monitoring is essential.
Treatment is personalized to each patient’s need, whether that means surgical removal of the tumor, or radiosurgery when traditional surgery is not a good option. The program also offers patients the possibility of being placed into a clinical trial, which can provide them with innovative and developing treatments.
Surgical treatments
Nonsurgical treatments
Rasopathiesnet.org rasopathiesnet.org
Li-Fraumeni Syndrome Association lfsassociation.org
Neurofibromatosis Network nfnetwork.org
Noonan Syndrome Foundation teamnoonan.org
Von Hippel-Lindau Alliance vhl.org
Tuberous Sclerosis Alliance tsalliance.org
