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Originally published February 12, 2025
Last updated February 12, 2025
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They call it the “French Paradox”: the observation that French people have low rates of coronary heart disease despite eating a diet rich in butter, cheese and all the other “good stuff” we’re told is bad for us.
So, what’s the secret? Maybe it’s the red wine, scientists hypothesized — because among the “good stuff” that many French people also enjoy is plenty of red wine.
But before you raise a glass to your own heart’s delight, consider what Danielle Trafficanda-Raynor, MS, RDN, a clinical dietitian with Keck Medicine of USC and USC Verdugo Hills Hospital, wants you to know about red wine and heart health. Because we’ve learned a lot about this paradox since it first captured researchers’ imaginations.
To be sure, red wine is rife with compounds that deliver scientifically substantiated heart health perks. And, as Trafficanda-Raynor explains, the source of those compounds is literally skin-deep.
“The highlight of red wine is that it’s made with the grape skins still on,” she says, “which is different from how white wine is made. And the skins of the grapes are what contain the heart-healthy compounds.”
Highest profile among them is a polyphenolic antioxidant known as resveratrol. Resveratrol has attracted attention for reducing LDL cholesterol and blood sugar levels, while increasing HDL cholesterol and promoting blood flow, in addition to acting as an anti-inflammatory and supporting heart health in a number of other ways.
“Some studies have even shown that red wine can help with gut health because its polyphenols have antioxidant and anti-inflammatory properties that can protect your gut microbiome,” Trafficanda-Raynor adds.
So, there’s definitely some truth to the notion that moderate red wine consumption pays cardiovascular benefits and more.
“The problem,” she goes on, “is that getting the amount you’d need to be beneficial requires drinking a lot — like 500 to 2,000 liters of red wine to get one gram of resveratrol. And it’s recommended that we have no more than one to two alcoholic beverages per day. That’s only four to five ounces of wine.”
Drink much more than this and “the costs outweigh the benefits pretty quickly,” she says.
One such cost is weight gain. A four-ounce glass of red wine comes in at about 120 calories, Trafficanda-Raynor says — and, as she quips, “Who’s stopping at four ounces?” So if red wine consumption causes you to gain weight, that can actually compromise heart health, increasing risk for high cholesterol levels, high blood pressure and type 2 diabetes.
What’s more, immoderate alcohol consumption poses risks beyond the heart, such as the development of fatty liver disease and crippling addiction.
That’s why Trafficanda-Raynor doesn’t advocate taking up red wine consumption as a cardioprotective measure. But she believes there is room for it in a heart-healthy lifestyle if you follow a few guidelines:
While red wine may be “the ‘better’ choice” among alcohol options, Trafficanda-Raynor says, “You don’t need red wine for heart health. Red wine does not equal healthy. You’re better off having grape juice — or, even better, a bowl of grapes!”
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