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Our USC Sarcoma Program specialists provide state-of-the-art treatments and surgeries to treat all types of sarcomas.
Sarcoma is the name given to cancers that arise from the bones and soft tissues, including fat, muscle and blood vessels. Bone sarcomas usually occur in children and adolescents, while soft tissue sarcomas are more common in adults. Our USC Sarcoma Program specialists are experts in treating this rare type of cancer.
Because sarcoma is so rare, your treatment should be done at a specialized center with physicians who have experience and expertise in this specific disease. Research demonstrates that patients have better outcomes when seen by sarcoma specialists. Our team offers access to a combination of effective treatment options, including surgery, radiation therapy, immunotherapy, chemotherapy, targeted therapies and clinical trials evaluating novel therapeutics.
Surgery for sarcoma is also best performed by a surgical oncologist (cancer surgeon) specifically trained to manage this frequently challenging disease. A sarcoma specialists’ deep knowledge of the disease is crucial to getting the right care.
Sarcomas are very rare compared to other types of cancer. There are more than 1 million new cancer cases each year. Just 12,000 of those are sarcomas. Sarcomas make up just 1% of cancer cases in adults.
There is also a wide variation in types of sarcomas. There are more than 70 subtypes of soft tissue sarcoma, some of which are very slow growing and almost benign, whereas others grow rapidly and are very aggressive. Some of the more common subtypes are:
Because sarcomas are so rare and have such a wide range of subtypes, it’s important to see a sarcoma specialist who has extensive experience with these kinds of tumors.
Sarcoma can start as a new, painless lump. Pain can occur (for example, if the tumor is compressing a major nerve), but it’s not common. Sometimes sarcomas do not cause any symptoms and are detected when a patient sees a doctor for other issues. In general, any new lump or mass should be checked out.
Sarcoma can occur anywhere in the body. The most common location is in the legs and arms. About 20% of sarcomas appear in the back of the abdomen, which is also known as the retroperitoneum. Sarcomas in this location often grow to a very large size before they are detected.
The cause for the vast majority of sarcoma subtypes is unknown. Some sarcomas may be hereditary, and some factors like radiation treatment for another cancer can raise a person’s risk for developing specific subtypes of sarcoma. Importantly, current research suggests that sarcoma is not linked to smoking, diet, obesity or specific lifestyle habits.
If you suspect you have a soft tissue sarcoma, your doctor may have you undergo an MRI or CT scan, followed by a biopsy. There are two types of biopsy:
A pathologist looks at the biopsy tissue under a microscope to look for cancer cells to make the diagnosis. Sarcoma can be hard to diagnose, so it’s important to have the biopsy reviewed by a trained sarcoma pathologist. Diagnosing the correct subtype of sarcoma is key to building the right treatment plan.
Depending on the subtype, further studies may be needed to determine if the sarcoma has spread. This often includes a CT scan of the chest, as the most common location of spread is the lungs. Occasionally, a whole-body PET scan is done to simultaneously look at the lungs and other potential sites, such as the liver. A PET scan also provides additional information about tumor activity. This can be used to monitor response to treatment, for example, before and after drug therapy.
For sarcomas that have not spread, surgery is the main treatment. Your surgeon will work to remove the tumor completely while still saving critical organs and structures (such as blood vessels and nerves) if possible. Depending on the case, a care team may also recommend chemotherapy or radiation therapy to ensure the best possible outcome.
Patients with sarcomas that have already spread or that cannot be removed by surgery usually undergo drug therapy. This includes traditional chemotherapy. In the last few years, newer drugs have become available for sarcomas, including better targeted therapies and immunotherapy.
Sarcoma cases vary so much that each patient will have a different prognosis. Your surgeon will take time to talk to you about your sarcoma subtype, your treatment plan and what you can expect.
Unfortunately, most sarcomas can come back. It’s important to have regular follow-up visits with a sarcoma specialist and get MRI or CT scans, as recommended, for a minimum of two or three years following treatment. In some cases, follow-up scans may be recommended for a longer period of time or indefinitely. If your specialist sees no evidence of disease over time, you may transition to ultrasound or X-rays. Since each case is different, your care team will design a unique plan just for you and keep updating it based on your scan results.
Our doctors have decades of experience in sarcoma treatment.
We have the most experienced multidisciplinary sarcoma team in Southern California.
Multiple studies have documented that patient outcomes are better at sarcoma centers with multidisciplinary teams and high patient volumes like we have at Keck Medicine of USC.
