USC MS and Neuroimmunology Center

From a multiple sclerosis diagnosis to treatment and rehabilitation, our specialists offer all-inclusive care to help you stay active and healthy.

USC MS and Neuroimmunology Center

From a multiple sclerosis diagnosis to treatment and rehabilitation, our specialists offer all-inclusive care to help you stay active and healthy.

Support our efforts to advance and innovate Multiple Sclerosis care.

Participating in a clinical trial gives you access to new and promising therapies.

Make a gift

Fellowships

Multiple Sclerosis Fellowship Program

Learn more

Patient-centered Comprehensive Care for Multiple Sclerosis

Multiple sclerosis (MS) affects your brain, spinal cord and the nerves to your eyes. Symptoms vary, from loss of muscle control to vision trouble. At the USC MS and Neuroimmunology Center, we provide a full spectrum of medical, nursing and support services to assist you and your loved ones on your healing journey.

With over 80 years of combined experience, our world-renowned leadership develops cutting edge research and clinical care and leads a multidisciplinary team that is focused on treating a diverse patient population.

At the center, our team will learn about your symptoms and create a multiple sclerosis treatment plan geared to you. We have extensive experience with the latest FDA-approved treatments. We’ll help you develop a healthy, meaningful lifestyle suited to your needs and goals.

Our highly trained staff is here to help navigate the coordinated care and treatment and any clinical concerns and  questions.

Research shows that multidisciplinary care is integral to comprehensively supporting individuals living with Multiple Sclerosis (MS) in meeting individualized health needs and achieving improved healthcare outcomes. The USC MS multidisciplinary team is comprised of MS experts who represent varied health disciplines including medicine, neuro-ophthalmology, neuropsychology, neuroradiology, neurosurgery, nursing, occupational therapy, physical therapy, primary care providers, psychiatry, rheumatology, social work, specialty pharmacy, and urology.

Why choose us for Multiple Sclerosis treatment and care

  • Our world-renowned physicians use the latest diagnostic techniques.
  • We’re known for compassionate care, education and research.
  • You’ll receive personalized, long-term MS management in a community-based setting.

Recognized leaders in Multiple Sclerosis care

  • The USC Multiple Sclerosis Comprehensive Care Center is a member of CMSC which recognizes the center to provide comprehensive care for people with multiple sclerosis (MS), including the ability to evaluate and manage medical, psychological, social, and rehabilitative issues, offer educational programs for patients, caregivers, and professionals and be active in the MS research community
  • We are recognized as a Center for Comprehensive MS Care by NMSS, acknowledging our leadership in addressing the needs of those living with MS through coordinated multi-disciplinary care including: medical, psycho-social, and rehabilitation services
  • Race to Erase MS Center Without Walls: Recognized as one of the top MS institutions that have established leading, innovative research programs

Multidisciplinary Care for MS

Research shows that multidisciplinary care is integral to comprehensively supporting individuals living with Multiple Sclerosis (MS) in meeting individualized health needs and achieving improved healthcare outcomes. The USC MS multidisciplinary team is comprised of MS experts who represent varied health disciplines including medicine, nursing, occupational therapy, physical therapy, social work, psychiatry, and specialty pharmacy. The team works together to address patient needs, problem-solve through challenging circumstances, and identify services, resources, and strategies to best support each individual living with MS and their care partners.

While people living with MS may not need to work with all members of the team at the same time, it is important to seek out and work with each profession as the need arises to achieve healthcare goals and improve function and quality of life.

Occupational Therapy in Multiple Sclerosis (MS)

Rebecca Cunningham OTD, OTR/L, MSCS

Rebecca Cunningham received her master’s and doctorate of occupational therapy degrees from the University of Southern California. Her clinical residency was completed at the USC Occupational Therapy Faculty Practice, where she provided Lifestyle Redesign® services and focused on further development of the Lifestyle Redesign program for individuals living with Multiple Sclerosis. As a clinical faculty member at the USC Occupational Therapy Faculty Practice, Dr. Cunningham works with clients in the Multiple Sclerosis, chronic pain and headaches and mental health programs, and is a member of the USC Multiple Sclerosis multidisciplinary team.

Physical Therapy in Multiple Sclerosis (MS)

Nora Darakjian, PT, DPT

Dr. Nora Darakjian is a physical therapist at USC Physical Therapy at the Health Science Campus. She specializes in treating patients with neurologic and vestibular disorders. Dr. Darakjian is board-certified by the American Board of Physical Therapy Specialties as a neurologic clinical specialist. She is a member of the Neurologic Section of the American Physical Therapy Association. She works in collaboration with the interdisciplinary team at USC Multiple Sclerosis Comprehensive Care Center.

Dr. Darakjian is also a clinical instructor in the doctor of physical therapy program in the neurologic content in the second year of the physical therapy curriculum. She is a clinical mentor in the neurologic physical therapy residency program

Social Work in Multiple Sclerosis (MS)

Kara Lynn Barton, LCSW
Licensed Social Worker, Social Worker, Neurology

Kara Barton, MSW, LCSW is a clinical social worker at the Keck Medical Center of University of Southern California in the Department of Neurology and in private practice. She provides resources and referrals for neurology patients and their families, and psychotherapy for individuals, couples, families and groups. She has facilitated various support groups for caregivers and people living with Epilepsy, Multiple Sclerosis, Parkinson’s Disease, a writing group, a mindfulness meditation group, and is certified as a trauma-informed yoga instructor. She created a short documentary, “We Live Among You”, about ableism and the invisible symptoms of Multiple Sclerosis. She works from a strengths-based, trauma-informed perspective, with self-compassion and mindfulness tools to expand capacity for coping with the unknown and the unexpected. She finds joy in connecting with people and connecting people to resources that improve quality of life.

The NMO Clinic at the Roski Eye Institute

At the Roski Institute at USC Keck, our specialized Neuroimmunology and Neuro-Ophthalmology teams collaborate to provide comprehensive care for patients with confirmed or suspected Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Neuromyelitis Optica Spectrum Disorder (NMOSD) and related disorders.

NMO is a rare neuroimmune condition in which the immune system attacks cells in the central nervous system (CNS), mistaking them for foreign invaders. Common symptoms include vision loss, color vision deficiency, paralysis, paraparesis, weakness, numbness, spasticity, vomiting, hiccups, and bladder/bowel dysfunction.

Our mission is to reduce the burden of lasting damage to your nervous system. At the NMO clinic, we bring you a detailed understanding of NMO so you can get the care you need. Your team may include neurologists, ophthalmologists, radiologists and other experts.

Prior to their appointment, all patients undergo advanced imaging with Optical Coherence Tomography (OCT) and visual field testing to assess the structure and function of the optic nerve. During the visit, patients are jointly evaluated by both the Neuroimmunology and Neuro-Ophthalmology specialists, ensuring a thorough assessment and the creation of a shared, individualized medical plan. This multidisciplinary approach prioritizes integrated care for patients with these complex neuroimmune conditions.

In addition to short-term care, our doctors design personalized long-term plans to manage your condition.

NMO Providers

Dr. Lilyana Amezcua, Neurology/Neuroimmunology

Dr. Amezcua is an Associate Professor of Neurology, and chief of the Multiple Sclerosis and Neuroimmunology Division. She serves as the medical director of the Neuromyelitis Optica and MOG clinic at Keck Medicine of the University of Southern California.

 

Dr. Masoud Majed, Neurology/Neuroimmunology

Masoud Majed, MD is a neuroimmunologist who completed his residency at UT Southwestern, a fellowship in Autoimmune Neurology at the Mayo Clinic, and an MS fellowship at Washington University. Dr. Majed is an expert in MOGAD, NMO, autoimmune encephalitis, autoimmune myelitis, paraneoplastic neurologic syndromes, and neurosarcoidosis.

 

Dr. Jeffrey Gluckstein, Neuro-Ophthalmology

Jeffrey Gluckstein is a neurologist and neuro-ophthalmologist. He provides consultation for conditions affecting the connections between the eye and brain and the processing of visual stimuli. He sees patients with conditions affecting the optic nerve, visual pathways in the brain, and nerves of the eye.

USC MULTIPLE SCLEROSIS and NEUROIMMUNOLOGY Clinical Trials

Available Clinical Trials

Status

Contact

A Long-Term, Prospective, Observational, Registry of Patients with Anti-Aquaporin 4 Antibody-Positive (AQP4+) Neuromyelitis Optica Spectrum Disorder (NMOSD) Treated with Alexion Complement Component 5 (C5) Inhibitor Therapies (ALXN-C5IT) Enrolling Sara Reasbeck sreasbec@usc.edu
T cell recognition of autoantigens in MOG antibody-associated disorder Enrolling Sara Reasbeck sreasbec@usc.edu
Multiple Sclerosis in the Hispanic population Enrolling Andrea Martinez Mart452@usc.edu Or Sarah Reasbeck sreasbec@usc.edu
Acculturation, Genetic Ancestry, and Disability in Hispanic Americans with Multiple Sclerosis Enrolling Andrea Martinez Mart452@usc.edu Or Sarah Reasbeck sreasbec@usc.edu
Immunology of Advancing Disease Among Minorities with Multiple Sclerosis Enrolling Sara Reasbeck sreasbec@usc.edu
Analysis of Chemokine and Cytokine Expression in the Different Stages of Multiple Sclerosis (MS) Following Different Treatment Regiments Enrolling Sara Reasbeck sreasbec@usc.edu
Effect of fasting mimicking diet on measures of function and inflammatory disease in relapsing multiple sclerosis (RMS) patients treated with standard disease modifying therapies (FMDMS)

https://clinicaltrials.gov/study/NCT06515782

Enrolling Frida Hovik fhovik@usc.edu
Performance and Safety of a Digital Tool for the Unsupervised Self-Assessment of Neuromyelitis Optica Spectrum Disorder Enrolling Sara Reasbeck sreasbec@usc.edu
An Open-Label, Multicenter Study to Access Disease Activity and Biomarkers of Neuronal Damage in Minority Patients with Relapsing Multiple Sclerosis Receiving Treatment with Ocrelizumab Enrollment Ended Andrea Martinez Mart452@usc.edu Or Sarah Reasbeck sreasbec@usc.edu
A Phase 3, Randomized, Double-Blind, Efficacy and Safety Comparing SAR442168 to Placebo in Participants with Primary Progressive Multiple Sclerosis (PERSEUS) Enrollment Ended Sara Reasbeck sreasbec@usc.edu
A Phase 3, Randomized, Double-Blind, Efficacy and Safety Study Comparing LTS17043 to Placebo in Participants with Non-Relapsing Secondary Progressive Multiple Sclerosis (LTS17043) Enrollment Ended Sara Reasbeck sreasbec@usc.edu
FREVIVA – Randomized, double-blind, placebo-controlled, parallel group Phase 3 study of Frexalimab in Adults with Nonrelapsing Secondary Progressive MS –https://clinicaltrials.gov/study/NCT06141486 Enrolling Rama Koppula koppula@usc.edu
AGNOS – Study of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls.     https://clinicaltrials.gov/study/NCT05084638 Enrollment Ended Rama Koppula koppula@usc.edu
Imaging MS at 7T Enrolling Genevieve Rodriguez Genevieve.Rodriguez@med.usc.edu

Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis (CAVS-MS)

https://clinicaltrials.gov/study/NCT04495556

Enrollment Ended Genevieve Rodriguez Genevieve.Rodriguez@med.usc.edu

 

Support our efforts to advance and innovate Multiple Sclerosis care.

Participating in a clinical trial gives you access to new and promising therapies.

Make a gift

Fellowships

Multiple Sclerosis Fellowship Program

Learn more

World-class Care

Our physicians and clinicians are dedicated to delivering high-quality, comprehensive care. We are leaders in cutting-edge treatments, breakthrough research and exceptional outcomes.

Christina Azevedo, MD (MS and Neuroimmunology)

Margaret Burnett, MD (MS and Neuroimmunology)

Masoud Majed, MD (MS and Neuroimmunology)

Leslie Tarlow, NP (Clinical Neurology, Multiple Sclerosis)

 

Lilyana Amezcua, MD, MS, FANN

Division Chief